Moritz Glaser
Hi, I'm a student researcher working on biological AI applications like mutation effect prediction.
I study computer science at Technical University Berlin and previously studied medicine for a year at Charité - University Hospital Berlin. I'm also a scholar of the German Academic Scholarship Foundation.
Research
My research focuses on mutation effect prediction and improving generalization of ESM-Effect. I also explore RL and interpretability research, comparing AlphaFold2 and ESM-2.
Publications
ESM-Effect: An Effective Fine-Tuning Framework for Mutation Effect Prediction
Moritz Glaser, Johannes Brägelmann
Tackling functional effect prediction by fine-tuning PLMs on DMS data achieving SOTA performance and x4.7 faster training compared to multi-modal SOTA models. Also introducing a Benchmarking Framework testing on distinct sequence intervals to probe generalization and using the Bin-Mean-Error metric emphasizing prediction performance on rare Gain-of-Function mutations relevant to targeted cancer therapy.
Clinicopathologic and molecular characteristics of small-scale ROS1-mutant non-small cell lung cancer (NSCLC) patients
Moritz Glaser, Anna Rasokat, Darinka Prang, Lucia Nogova, Claudia Wömpner, Jaqueline Schmitz, Elisabeth Bitter, Inken Terjung, Anna Eisert, Rieke Fischer, Felix John, Cornelia von Levetzow, Sebastian Michels, Richard Riedel, Lea Ruge, Heather Scharpenseel, Udo Siebolts, Sabine Merkelbach-Bruse, Reinhard Buettner, Jürgen Wolf and Matthias Scheffler
Comprehensive analysis of ROS1 mutations in NSCLC, providing insights into patient characteristics and treatment outcomes.
Curriculum Vitae
Download my CV: PDF